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Description
Alexa Fluor® 647 Mouse Anti-Mouse LAP (TGF-β1) Antibody (S-R680)Product Specification Host Mouse Antigen LAP (TGF 1) Synonyms Transforming growth factor beta 1 proprotein; Tgfb1 Location Secreted, Extracellular space Accession P04202 Clone Number S R680 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | LAP (TGF-β1) |
| Synonyms | Transforming growth factor beta-1 proprotein; Tgfb1 |
| Location | Secreted, Extracellular space |
| Accession | P04202 |
| Clone Number | S-R680 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
TGF-β1 (Transforming Growth Factor-beta 1) is a multifunctional cytokine belonging to the TGF-β superfamily, playing a pivotal role in cell proliferation, differentiation, apoptosis, immune regulation, extracellular matrix formation, and tissue repair. Synthesized as an inactive precursor, it undergoes proteolytic activation to form a biologically active homodimer. TGF-β1 signals through binding to TGF-β receptors (Type I/II), triggering both Smad-dependent (canonical) and Smad-independent (non-canonical, e.g., MAPK, PI3K) pathways. Critical in embryogenesis, wound healing, and fibrosis, TGF-β1 exhibits dual roles in disease—acting as a tumor suppressor early in cancer but promoting metastasis in advanced stages. Dysregulation is linked to fibrotic disorders (e.g., pulmonary fibrosis), autoimmune diseases, and cancer progression. Its context-dependent functions (anti-inflammatory vs. pro-fibrotic/tumorigenic) are influenced by microenvironmental cues, making it a therapeutic target for fibrosis, cancer, and inflammatory conditions.
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Exchange/Return Notes
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