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Description
Phospho-Akt Substrate (RXXST) Recombinant Rabbit mAb (S-2669-104)Product Specification Host Rabbit Antigen Phospho Akt Substrate (RXXST) Immunogen Synthetic Peptide Clone Number S 2669 104 Antibody Type Recombinant mAb Isotype IgG Application WB Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution application
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Akt Substrate (RXXST) |
| Immunogen | Synthetic Peptide |
| Clone Number | S-2669-104 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
The Phospho-Akt Substrate (RXXS*/T*) antibody is a specific antibody primarily used to identify and detect substrate proteins phosphorylated by Akt kinase and other related AGC kinase family members. This antibody recognizes protein sequences containing phosphorylated serine or threonine (S*/T*), with the key feature being the presence of an arginine (R) at the -3 position, forming the characteristic R-X-X-pS/pT motif. Within cellular signal transduction, Akt kinase is the central component of the PI3K/Akt pathway, which regulates critical biological processes such as cell growth, survival, proliferation, and metabolism. By targeting this specific phosphorylation motif, the antibody can be employed in various experimental techniques like Western Blot, immunoprecipitation, and immunohistochemistry. This enables researchers to systematically study Akt signaling pathway activity, discover novel downstream substrates, and investigate its role in diseases such as cancer and diabetes.
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