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Description
CCL1 Protein, HumanProduct Specification Species Human Synonyms Small inducible cytokine A1,T lymphocyte secreted protein I 309 Accession P22362 Amino Acid Sequence Ser23 Lys96 Expression System E. coli Molecular Weight Approximately 8. 6 kDa, a single non glycosylated polypeptide chain containing 74 amino acids. Purity 98% by SDS PAGE or HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 20 mM PB, with 150 mM NaCl, pH 7. 4.
Product Specification
| Species | Human |
| Synonyms | Small-inducible cytokine A1,T lymphocyte-secreted protein I-309 |
| Accession | P22362 |
| Amino Acid Sequence | Ser23-Lys96 |
| Expression System | E.coli |
| Molecular Weight | Approximately 8.6 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids. |
| Purity | ＞98% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20 mM PB, with 150 mM NaCl, pH 7.4. |
| Reconstitution |
Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
Chemokine (C-C motif) ligand 1 (CCL1) belongs to a family inflammatory cytokine (also known as chemokines) . It is a small glycoprotein secreted by activated T cells with a molecular weight of approximately 8.5kDa. CCL1 signals through the CCR8 receptor. Human CCL1 has been assumed to be a homologue of the mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. Recombinant Human I-309 is an 8.6kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric.
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