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Description
Tau (phospho S214) Recombinant Rabbit mAb (S-1032-326)Product Specification Host Rabbit Antigen Tau (phospho S214) Synonyms Microtubule associated protein tau; Neurofibrillary tangle protein; Paired helical filament tau (PHF tau); MAPTL; MTBT1; TAU; MAPT Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Secreted, Cell membrane, Endoplasmic reticulum Accession P10636 8 Clone Number S 1032 326 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample old mouse brain
Product Specification
| Host | Rabbit |
| Antigen | Tau (phospho S214) |
| Synonyms | Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau (PHF-tau); MAPTL; MTBT1; TAU; MAPT |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Secreted, Cell membrane, Endoplasmic reticulum |
| Accession | P10636-8 |
| Clone Number | S-1032-326 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | old mouse brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Ms |
Background
Tau (phospho S214) protein is a phosphorylated form of the tau protein, which is a microtubule-associated protein primarily found in neurons of the central nervous system. It is encoded by the MAPT gene and plays a crucial role in maintaining the stability and promoting the assembly of microtubules in axons. The phosphorylation of tau at serine 214 (S214) by cAMP-dependent protein kinase A (PKA) has been shown to reduce the pathological assembly of the protein. This phosphorylation event is significant as it can influence the protein's binding affinity to microtubules and its involvement in neurofibrillary tangles, which are a hallmark of Alzheimer's disease and other tauopathies.
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