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Description
Phospho-PKR (Thr446) Recombinant Rabbit mAb (S-771-17)Product Specification Host Rabbit Antigen Phospho PKR (Thr446) Synonyms Interferon induced, double stranded RNA activated protein kinase; Eukaryotic translation initiation factor 2 alpha kinase 2 (eIF 2A protein kinase 2); Interferon inducible RNA dependent protein kinase; P1 eIF 2A protein kinase; Protein kinase RNA activated (PKR; Protein kinase R); Tyrosine protein kinase EIF2AK2; p68 kinase; PKR; PRKR; EIF2AK2 Immunogen Synthetic Peptide Location
Product Specification
| Host | Rabbit |
| Antigen | Phospho-PKR (Thr446) |
| Synonyms | Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2); Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated (PKR; Protein kinase R); Tyrosine-protein kinase EIF2AK2; p68 kinase; PKR; PRKR; EIF2AK2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P19525 |
| Clone Number | S-771-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:500 | Hu |
Background
Protein Kinase R (PKR), also known as double-stranded RNA-dependent protein kinase, is a key enzyme involved in the innate immune response to viral infections. It is an interferon-induced, serine/threonine protein kinase that becomes activated upon binding to double-stranded RNA (dsRNA), which is often produced during viral replication. Once activated, PKR phosphorylates the eukaryotic initiation factor 2α (eIF-2α), inhibiting protein synthesis and thus limiting viral replication. Additionally, PKR plays roles in regulating apoptosis, cell growth, and differentiation, and has been implicated in cancer and metabolic diseases. Its versatile functions make it a significant target for therapeutic research.
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