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Description
Mouse Tim-4 Protein, His TagProduct Specification Species Mouse Synonyms T cell immunoglobulin and mucin domain containing protein 4, TIMD 4, Spleen, mucin containing, knockout of lymphotoxin protein (SMUCKLER), T cell immunoglobulin mucin receptor 4 (TIM 4), T cell membrane protein 4 Accession Q6U7R4 Amino Acid Sequence Protein sequence (Q6U7R4, Ala23 Thr279, with C His Tag)
Product Specification
| Species | Mouse |
| Synonyms | T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, Spleen, mucin-containing, knockout of lymphotoxin protein (SMUCKLER), T-cell immunoglobulin mucin receptor 4 (TIM-4), T-cell membrane protein 4 |
| Accession | Q6U7R4 |
| Amino Acid Sequence | Protein sequence (Q6U7R4, Ala23-Thr279, with C-His Tag) ASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINSRQT |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 29.5 kDa Observed MW: 75-100 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
TIMD-4, also known as TIM-4, is a member of the T-cell immunoglobulin and mucin domain (TIM) family, which plays a crucial role in immune regulation. Expressed primarily on antigen-presenting cells (APCs), such as macrophages and dendritic cells, TIMD-4 binds to phosphatidylserine (PS) on apoptotic cells, mediating their phagocytic clearance and maintaining immune tolerance. It also interacts with TIM-1 on T cells, influencing T-cell activation and cytokine production. TIMD-4 is implicated in autoimmune diseases, allergies, and infections due to its role in modulating immune responses.
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