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Description
FITC-Labeled MSLN/Mesothelin Fc Chimera Protein, HumanProduct Specification Species Human Synonyms MSLN Mesothelin,MPF,SMRP Accession Q13421 1 Amino Acid Sequence Glu296 Gly580, with C hIgG1 Fc Expression System HEK293 Molecular Weight 70 85kDa Conjugation FITC Tag Human IgG1 Fc Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date of receipt, lyophilized powder stored at 20 to 80. 3 months, 20 to 80 under sterile conditions after reconstitution. 1 week, 2 to 8
Product Specification
| Species | Human |
| Synonyms | MSLN/Mesothelin,MPF,SMRP |
| Accession | Q13421-1 |
| Amino Acid Sequence | Glu296-Gly580, with C-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 70-85kDa |
| Conjugation | FITC |
| Tag | Human IgG1 Fc |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1、Chang K. et al. (1996) Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. PNAS. 93(1): 136-140. |
Background
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte potentiating factor, which belongs to the mesothelin family. Mesothelin/MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin/MSLN can interacts with MUC16. The membrane-anchored form of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro. Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers. The restricted expression of MSLN in normal tissue and its frequent expression in cancers make MSLN an excellent target for antibody-based therapies.
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