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Description
APC-Cy7 Rat Anti-Mouse/Human CD11b Antibody (S-R574)Product Specification Host Rat Antigen CD11b Synonyms Integrin alpha M; CD11 antigen like family member B; CR 3 alpha chain; Cell surface glycoprotein MAC 1 subunit alpha; Leukocyte adhesion receptor MO1; Itgam Location Cell membrane Accession P05555P11215 Clone Number S R574 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Hu, Ms Positive Sample human peripheral blood cells Purification Protein G Concentration 0. 05mg ml Conjugation
Product Specification
| Host | Rat |
| Antigen | CD11b |
| Synonyms | Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Itgam |
| Location | Cell membrane |
| Accession | P05555、P11215 |
| Clone Number | S-R574 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | human peripheral blood cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | APC-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu, Ms |
Background
CD11b, also known as integrin alpha M or CR3A, is a key component of the integrin family, primarily expressed on the surface of immune cells such as macrophages, monocytes, neutrophils, and natural killer cells. It forms a heterodimer with CD18 (integrin β2) to function as a receptor for various molecules, including the iC3b fragment of complement protein, fibrinogen, factor X, and ICAM-1. This receptor complex plays a crucial role in mediating cell adhesion, migration, and the uptake of pathogens and complement-coated particles. Additionally, CD11b is widely used as a marker for identifying macrophages and other immune cells in research. Its involvement in immune responses and cell signaling makes it an important target in studies related to inflammation, immune regulation, and certain diseases.
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