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For Your Every Summer RSVP, with Code: SUMMER15
Description
p16 Recombinant Rabbit mAb, PBS Only (SDT-303-206)Product Specification Host Rabbit Antigen p16 Synonyms Cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase 4 inhibitor A (CDK4I); Multiple tumor suppressor 1 (MTS 1); p16 INK4a (p16 INK4; p16INK4A); CDKN2A Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P42771 Clone Number SDT 303 206 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu Purification Protein A Concentration 2 mg ml
Product Specification
| Host | Rabbit |
| Antigen | p16 |
| Synonyms | Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A (CDK4I); Multiple tumor suppressor 1 (MTS-1); p16-INK4a (p16-INK4; p16INK4A); CDKN2A |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P42771 |
| Clone Number | SDT-303-206 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:4000 | |
| IP | 1:200 | |
| IHC-P | 1:250 | |
| ICC | 1:2000 | |
| ICFCM | 1:2000 |
Background
p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). p16 is also implicated in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer and esophageal cancer.
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