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Description
NEK7 Recombinant Rabbit mAb (S-2494-70)Product Specification Host Rabbit Antigen NEK7 Synonyms Serine threonine protein kinase Nek7; Never in mitosis A related kinase 7 (NimA related protein kinase 7) Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus Accession Q8TDX7 Clone Number S 2494 70 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample Jurkat, HeLa, NIH 3T3, PC 12, COS 7 Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | NEK7 |
| Synonyms | Serine/threonine-protein kinase Nek7; Never in mitosis A-related kinase 7 (NimA-related protein kinase 7) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | Q8TDX7 |
| Clone Number | S-2494-70 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | Jurkat, HeLa, NIH/3T3, PC-12, COS-7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:100 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
NEK7, a 34.5 kDa serine/threonine kinase of the NIMA-related family, is essential for mitotic entry, spindle organization and cytokinesis through phosphorylation of substrates such as EML4 and RPS6KB1, and is also indispensable for NLRP3 (and possibly NLRP1) inflammasome activation downstream of K⁺ efflux, where it binds NLRP3 via its catalytic domain—without requiring kinase activity—to promote oligomerization, ASC speck formation and caspase-1-dependent IL-1β/IL-18 release, thereby acting as a switch that mutually excludes mitosis from inflammasome signaling and links cell-cycle control to innate immunity and inflammatory diseases.
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