SKU: 7624033020

IL-29/IFN-λ1 Protein, Human

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Description

IL-29/IFN-λ1 Protein, HumanProduct Specification Species Human Synonyms IL29, IFNL1, IFN1, Interleukin 29, IFN lambda 1 Accession Q8IU54 Amino Acid Sequence Gly20 Thr200, with C terminal His Tag Expression System HEK293 Molecular Weight 30 35kDa(Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH 7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Human
Synonyms IL29, IFNL1, IFNλ1, Interleukin-29, IFN lambda 1
Accession Q8IU54
Amino Acid Sequence Gly20-Thr200, with C-terminal His Tag
Expression System HEK293
Molecular Weight

30-35kDa(Reducing)
Purity ＞95% by SDS-PAGE
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH 7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Hidese S. Search for cerebrospinal fluid biomarkers in patients with major psychiatric disorders: Multiplex immunoassay findings and proximity extension assay prospects. Neuropsychopharmacol Rep. 2024 Apr 30.
2.Sakashita E, Nagatani K, Endo H, Minota S. Biomarker combination predicting imminent relapse after discontinuation of biological drugs in patients with rheumatoid arthritis in remission. PLoS One. 2024 Mar 21;19(3):e0299450.

Background

Interleukin-29, is a secreted protein which belongs to the IL-28 / IL-29 family, and is a cytokine with immunomodulatory activity. It is also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, IFNλ1, IL-29 and IFNL1, and is highly similar in amino acid sequence to the IL-28, the other type III interferon. Human IL29 cDNA encodes a 200 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 181 aa mature protein, which is a monomer in solution. It shares 67% and 69% aa sequence identity with human IL28A and IL28B, respectively. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses and also may play a role in antiviral immunity. Interleukin-29 / IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

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Exchange/Return Notes
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SKU: 7624033020

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4.2 ★★★★★
Based on 6 reviews
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Product Reviews
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Verified Purchase
Blue
Bozeman, US
★★★★★ 5
LOVED IT!
LOVED IT! I’ve been using the Simple brand makeup wipes removers and they’re THE BEST I have tried especially since I have extremely sensitive skin. Even though this moisturizer is a bit(but just a tiny bit) greasy, I don’t mind because it’s REALLY moisturizing and it’s perfect for my combination skin. It’s a gel but it’s a bit watery. However, once you put some on your face your skin just drinks it in. You don’t need much of the product because just a small amount of product is needed. My face feels nice afterwards and soft. Bought 2 more for back ups. Also, yes it’s a small tube(which it’s perfect for traveling) but honestly a little bit goes a long way because you don’t need too much product since it’s a watery gel so I think the tube can last quite a bit! I love this brand and will look into trying some of their other products in the near future.
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Reviewed in the United States on April 30, 2020
M
Verified Purchase
M.B.
Battle Creek, US
★★★★★ 3
Does the job for less $
I bought this moisturizer when a move to California left my face looking its age for the first time in my life. The Arnica-infused Olive Oil I've been using for years was protecting my skin as a barrier, but not adding any hydration, and the drier climate forced a change. I was looking for something without synthetic fragrance, heavy oils, or a high price tag. Simple's Hydrating Gel Cream fit the bill, and I was curious about how a gel might feel. After a week of use I have noticed a few small spots which don't stay long, but my décolletage did produce some worrying pimples. I'm not ready to throw it out yet, because there are other factors to eliminate before passing judgement. My face is perceptively brighter and the skin under my eyes (main problem area) is improving. A little goes a long ways - so no need to fret over a mere 1.7oz. The gel does take a few moments to absorb, and I generally give it a few more minutes to sink in before I am able to apply a mineral sunscreen in the morning without "pilling." Also, I get a subtlely warm sensation on my face after having exfoliated - but there is no accompanying redness or lasting irritation - probably some of the fillers having a mild reaction on the surface. So far I'm willing to continue using this product because I think it's a good value for the price. Not sure I'd stick with it if I found something better though.
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Reviewed in the United States on February 18, 2020
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Verified Purchase
Kristin K. Cormier
Louisville, US
★★★★★ 5
The best product i have EVER used!!!!!!
This is honestly the best product i have EVER used. I’ve been using it for 2-3 years. I have super sensitive skin and for some reason my skin gets SUPER dehydrated. I have tried many products but nothing has worked as well as this. I swear by this hydrating moisturizer/gel and i recommend it to any and everyone. I do the upwards and outward motions like suggested and it instantly absorbs. It never feels sticky which is a HUGE plus. A little bit definitely goes a long way. I use it on my face, neck and other areas of my body that seems to feel dehydrated (elbows, knees and back of hands). I have heard from multiple people that my face has never looked more hydrated than it does right now. My favorite part is every time i apply it it always feel cool temperature wise. It leaves a cool and clean feeling like i have put a cool compress on my face. I would recommend this product 100x over and over.
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Reviewed in the United States on April 6, 2021
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Verified Purchase
Roxanne M.
Lake Worth, US
★★★★★ 5
Best cream ever!
I really love this “Simple” gel cream I hope they never stop making it. I have oily skin and other creams seem to just Irritate my skin or just feel thick and heavy like it’s blocking my pores. Not this cream. It feels light weight and yet moisturizing. It has no scent. I use it all over my face and my neck. I have bought department store moisturizers and yet I keep coming back to this Simple hydrating gel cream it never fails me. The only problem is I discovered I can’t find it in any of the stores anymore in my area, I don’t know why but I never thought to look for it here on Amazon. So now I’m a faithful purchaser of this product here on Amazon I love it so much I just hope the company still will continue to make it and that Amazon will continue to sell it.
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Reviewed in the United States on May 6, 2021
B
Verified Purchase
Bonnie
Pawtucket, US
★★★★★ 5
Is this the CURE!
Size: Regular, Color: Cream
I have a skin disease called Ichthyosis Vulgaris. Yes, SCALEY FISH! Thanks MOM! This unfortunate crud leaves my heels an embarrassing mess! They are cracked and dry and literally like concrete. I have had this disease all my life and there is NO cure. It's hideous! Anyway, I have tried so many different experiments to help improve my situation. So much time and money I will never get back. So when I saw these, I had to give them a try too because I am a forever optimist and love being disappointed. Here's how it went. First I put my dermatologist recommended AmLactin on my crusty heels. Then, I put the socks on. By the way, with no problem at all, and went to bed. I was not too hot, which is usually what happens when I sleep with socks on. I never even realized that I had them on. When I woke up, I took them off and immediately used a "Heel File" over a towel removing all the yuck!. Then, I sand papered them to smooth the skin out. Then, I doused them with Shea and Aloe foot lotion I found at the bottom of my experiment drawer in my bathroom. Oh, they felt like someone else's feet. I am very hopeful at this moment! Is this the cure to my embarrassing situation? I sure hope so. Spring is here and I would really like to wear my cute flip-flops when I go to the Waffle House and set at the bar. Wasn't that a picture on Facebook of someone nasty heels? It made me gag. Then, I had to make sure that picture wasn't me! I am going to do this for a week and come back for another review. Wish me luck ya'll! UPDATE! So it’s been about two weeks. I wish that I had taken a before and after picture. I guess I figure that this too will be a waste of money. NO! These little socks are a God send for me. I did buy AmLactin foot repair cream and that I highly recommend. It’s the best so far. They also offer an option with heel socks. They are soft and work very well also but one negative. They leave fuzzies on you feet and tools. Guys this is it for me. My search is over! I went to my mani/pedi queen yesterday and she was shocked when she saw my feet. She is spreading the word!
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Reviewed in the United States on March 23, 2025

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