SKU: 76384169650

MICB Recombinant Rabbit mAb (SDT-1472-102)

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Description

MICB Recombinant Rabbit mAb (SDT-1472-102)Product Specification Host Rabbit Antigen MICB Synonyms MHC class I polypeptide related sequence B; MIC B; Immunogen Recombinant Protein Accession Q29980 1 Clone Number SDT 1472 102 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against MICB, NKG2D Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03%

Product Specification


Host Rabbit
Antigen MICB
Synonyms MHC class I polypeptide-related sequence B; MIC-B;
Immunogen Recombinant Protein
Accession Q29980-1
Clone Number SDT-1472-102
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity

No cross-reactivity against MICB, NKG2D

Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Background

MHC I polypeptide-related sequence B (MICB) is a highly glycosylated transmembrane protein encoded by the MICB gene, located on chromosome 6p21.33. It functions as a ligand for the NKG2D receptor, a type II receptor expressed on natural killer (NK) cells, CD8+ T cells, and γδ T cells. The binding of MICB to NKG2D activates cytolytic responses in these immune cells, promoting the elimination of stressed or infected cells. Unlike MHC class I molecules, MICB does not associate with β-2-microglobulin or bind peptides. MICB is stress-induced, meaning its expression increases under cellular stress conditions, such as DNA damage or viral infection. This protein is widely expressed in various tissues, including lymph nodes and bone marrow, highlighting its role in immune surveillance. The external domains of MICB are proteolytically cleaved by surface proteases and shed into the extracellular space. MICB shedding by cancer cells causes effective escape from NKG2D recognition and allows the development of cancers. Patients frequently have increased concentrations of soluble MICA/B molecules shed in the blood plasmas and sera, thus indicating that MICA/B shedding is a therapeutic target in immune-oncology.

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SKU: 76384169650

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4.2 ★★★★★
Based on 23 reviews
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Denielle
Alexandria, US
★★★★★ 5
Great toys. Bouncy, chewable long term.
Size: Medium, Size: Medium
We got these for our puppy and to see how they would compare to kongs. Our dogs love these more than the kongs and so far, with two chewy dogs, they have not destroyed these yet. They are very bouncy and provide a lot of chasing fun. We will be buying more and we recommend these.
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Reviewed in the United States on February 28, 2026
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Lynn
Omaha, US
★★★★★ 4
Durable
Size: Large
Excellent material. I wish the hole was a little smaller to keep the treats in better. Also wish they were a little larger and/or oddly shaped so as not to fit under the sofa. Still totally worth it.
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Reviewed in the United States on January 10, 2025
M
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M Mon
West Palm Beach, US
★★★★★ 5
Subtle, great dog toy design!
Size: Large
These things are amazing. Stuff them with peanut butter and treats and freeze them of course, but football spike them across the yard to drive your overly hyped dog nuts! And the hole allows you to safely pry it out of a tug battle , just a great design! And it can bobble across a small living space without getting lost like a ball would. Love it!
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Reviewed in the United States on April 20, 2026
A
Verified Purchase
Austin Smith
Alexandria, US
★★★★★ 3
Treats fall out way to easy
Size: Large
Kinda sorta awful at holding treats in it, they just fall out without my dog even having to touch it really. I spread peanut butter on the inside of the toy and freeze it..works much better that way, nay, works amazing that way. I got this toy to stimulate his brain, so he’s either much smarter than every other dog or the treats fall out too easy..I believe it’s the ladder.
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Reviewed in the United States on May 26, 2025
A
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ABC Dog Pack
Alexandria, US
★★★★★ 5
Great for enrichment treats for dogs
Size: Large, Size: Large
Great product and durable. We fill them with wet dog food and freeze it then give it to our dogs as enrichment treats. They love it. It’s super easy to use and strong against dogs bites and chewing
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Reviewed in the United States on December 4, 2025

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