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Description
Insulin Recombinant Rabbit mAb (SDT-026-17)Product Specification Host Rabbit Antigen Insulin Synonyms INS Immunogen Synthetic Peptide Location Secreted Accession P01308 Clone Number SDT 026 17 Antibody Type Rabbit mAb Application IHC P, IF Reactivity Hu, Ms, Rt Predicted Reactivity Cz, Or, Mq, Pr, C. el Purification Protein A Concentration 0. 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | Insulin |
| Synonyms | INS |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P01308 |
| Clone Number | SDT-026-17 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Cz, Or, Mq, Pr, C.el |
| Purification | Protein A |
| Concentration | 0.1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | |
| IF | 1:400 |
Background
Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the INS gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially of reserve body fat.
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