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Description
Alexa Fluor® 647 Rat Anti-Mouse CD104 Antibody (S-R716)Product Specification Host Rat Antigen Integrin beta 4 Synonyms Integrin beta 4; Itgb4 Location Cell membrane Accession A2A863 Clone Number S R716 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample BALB c mouse thymocytes Purification Protein G Concentration 0. 5 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | Integrin beta 4 |
| Synonyms | Integrin beta-4; Itgb4 |
| Location | Cell membrane |
| Accession | A2A863 |
| Clone Number | S-R716 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
Integrin beta 4 (CD104) is a key subunit of the integrin family, primarily functioning as a receptor for laminins and often associating with the alpha 6 subunit to form the α6β4 integrin complex. This transmembrane glycoprotein receptor plays a crucial role in mediating cell-matrix adhesion and signaling, which regulates gene expression, cell growth, and migration. ITGB4 is particularly important in maintaining the stability of hemidesmosomes, which anchor epithelial cells to the basement membrane. Additionally, its expression and activity are implicated in various biological processes, including wound healing, tissue integrity, and cancer progression. Abnormal mutations or dysregulation of ITGB4 have been associated with diseases such as epidermolysis bullosa with pyloric atresia.
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