SKU: 79208417161

Pacific Blue Mouse Anti-Human CD62L Antibody (S-937-77)

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Description

Pacific Blue Mouse Anti-Human CD62L Antibody (S-937-77)Product Specification Host Mouse Antigen CD62L Synonyms L selectin; CD62 antigen like family member L; Leukocyte adhesion molecule 1 (LAM 1); Leukocyte surface antigen Leu 8; Leukocyte endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; LNHR; LYAM1; SELL Immunogen Recombinant Protein Location Cell membrane Accession P14151 Clone Number S 937 77 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample

Product Specification


Host Mouse
Antigen CD62L
Synonyms L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; LNHR; LYAM1; SELL
Immunogen Recombinant Protein
Location Cell membrane
Accession P14151
Clone Number S-937-77
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Pacific Blue
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD62L, also known as L-selectin, is a type I transmembrane glycoprotein and a member of the selectin family of adhesion molecules, primarily expressed on the surface of leukocytes, including T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and migration, facilitating the initial adhesion and rolling of white blood cells on endothelial cells, particularly in lymph nodes and inflamed tissues. CD62L is also a phenotypic marker for central memory T cells, which have a higher expression of this molecule and can rapidly respond to antigen re-exposure. In addition to its role in immune response and memory, CD62L has potential applications in cancer immunotherapy, where its regulation can enhance T cell infiltration into the tumor microenvironment and improve treatment outcomes.

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SKU: 79208417161

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