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Description
GHR Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms GHBP,GH receptor Accession Q3UP14 Amino Acid Sequence Thr25 Gln273 with hIgG1 Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 50 75kDa (Reducing) Purity 95% by SDS PAGE & > 90% by HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Mouse |
| Synonyms | GHBP,GH receptor |
| Accession | Q3UP14 |
| Amino Acid Sequence | Thr25-Gln273 with hIgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 50-75kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocr Rev. 2001 Feb;22(1):53-74. |
Background
Growth hormone receptor (GHR), also known as growth hormone-binding protein (GHBP), is a single-pass type I transmembrane protein belonging to the cytokine receptor family. Its structure contains a typical fibronectin type-III domain and is predominantly expressed in the liver and skeletal muscle, while various isoforms are distributed in multiple tissues such as the kidneys and placenta. Upon binding to pituitary-derived growth hormone, this receptor activates the JAK2/STAT5 signaling pathway to regulate body growth and metabolism. The soluble GHBP, formed through proteolytic cleavage of the extracellular domain, serves as a circulating reservoir for growth hormone and negatively modulates signal transduction. Clinically, GHR gene defects are directly linked to multiple growth disorders, including severe growth hormone resistance such as Laron syndrome—characterized by growth retardation and impaired insulin-like growth factor I production—as well as idiopathic short stature and other inherited growth abnormalities. Thus, GHR is not only a key regulator of growth but also an important diagnostic and therapeutic target for related endocrine disorders.
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