SKU: 9316929722

FITC Mouse Anti-Human CD314 (NKG2D) Antibody (S-4154)

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Description

FITC Mouse Anti-Human CD314 (NKG2D) Antibody (S-4154)Product Specification Host Mouse Antigen CD314 (NKG2D) Synonyms NKG2 D type II integral membrane protein; Killer cell lectin like receptor subfamily K member 1; NK cell receptor D; NKG2 D activating NK receptor; D12S2489E; KLRK1 Location Cell membrane Accession P26718 Clone Number S 4154 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation FITC

Product Specification


Host Mouse
Antigen CD314 (NKG2D)
Synonyms NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; D12S2489E; KLRK1
Location Cell membrane
Accession P26718
Clone Number S-4154
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD314, also known as NKG2D (Natural Killer Group 2D), is a type II transmembrane glycoprotein and a member of the C-type lectin-like receptor family that serves as an activating receptor expressed on the surface of natural killer (NK) cells, CD8+ T cells, γδ T cells, and NKT cells. It functions as a homodimeric receptor that recognizes stress-induced ligands, including MICA, MICB, and ULBP1-6 (UL16-binding proteins) in humans, which are upregulated on infected, transformed, or damaged cells due to cellular stress, DNA damage, or viral infection. Upon ligand engagement, NKG2D associates with the adaptor protein DAP10 (DNAX-activating protein of 10 kDa) through a charged transmembrane interaction, triggering phosphoinositide 3-kinase (PI3K)-dependent signaling pathways that promote cytotoxicity, cytokine production, and enhanced immune surveillance. Unlike many other NK cell receptors, NKG2D signaling is not inhibited by self-MHC class I molecules, making it a critical mechanism for distinguishing healthy cells from aberrant cells in the context of cancer immunosurveillance, viral defense, and autoimmune regulation. Dysregulation of the NKG2D-ligand axis has been implicated in various pathological conditions, including tumor immune evasion through ligand shedding or downregulation, as well as autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, highlighting its significance as a therapeutic target in immuno-oncology and immunotherapy development.

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SKU: 9316929722

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pdono
Whiting, US
★★★★★ 5
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Size: 25-Foot, Style: Expandable Fabric
This Camco EvoFlex2 25-ft drinking water hose is outstanding and a huge upgrade from standard RV hoses. The flexibility is incredible—it stays supple even in cold weather and coils up easily without kinking or fighting you. No more wrestling with stiff hoses during setup and takedown. The drinking water safe certification gives me peace of mind that I'm not contaminating my fresh water system. No plastic taste or smell in the water like you get with cheaper hoses. The 25-foot length is perfect for most campsite hookups without excess hose laying around. The fittings are quality brass that don't leak and thread smoothly onto connections. They feel substantial and durable—no cheap plastic components that'll crack or strip. The hose itself is tough and resists abrasion from being dragged across gravel and pavement. After multiple camping trips, it still looks and performs like new. Easy to clean and maintain between uses. The flexibility means it stores compactly without taking up much space in the RV storage compartment. If you're tired of dealing with stiff, kinky RV water hoses, upgrade to this EvoFlex2. It's worth every penny for the convenience and quality. Highly recommend!
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Reviewed in the United States on October 28, 2025
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Tom
Whiting, US
★★★★★ 5
Quick and easy to use and store
Size: 50-Foot, Style: Expandable Fabric
Great water hose. Easy and small to carry in motorhome bay. Don’t have the issue with trying to coil the hose up.
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Reviewed in the United States on April 19, 2026
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Ying
Belleville, US
★★★★★ 5
Light and easy to use
Size: 25-Foot, Style: Expandable Fabric
Very good product, like it, very light, easy to put back together, take a little space
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Reviewed in the United States on May 25, 2026
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Jim Knebusch
Houston, US
★★★★★ 4
Recommend purchase
Size: 25-Foot, Style: Expandable Fabric
This hose easily kinks, which restricts the flow. But it is easy to manage the kinks, you just need to be aware of them. It is easy to handle and store. Great quality. I will buy this hose again.
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Reviewed in the United States on June 9, 2026
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Rip
Grantham, US
★★★★★ 5
Very compact
Size: 50-Foot, Style: Expandable Fabric
The hose is flat, so it doesn’t take up much room, which is great. However, being flat, it’s way more challenging to roll it up, but overall still a really good hose.
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Reviewed in the United States on May 5, 2026

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