SKU: 81581957266

CD40/TNFRSF5 His Tag Protein, Cynomolgus

Sale price$243.00 Regular price$270.00
Save 10%

Pay in installments of $67.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 29 - Sep 3

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

CD40/TNFRSF5 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with C terminal His Expression System HEK293 Molecular Weight 26 33kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence Glu21-Arg193, with C-terminal His
Expression System HEK293
Molecular Weight

26-33kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 81581957266

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.4 ★★★★★
Based on 23 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
S
Verified Purchase
Sandra White
Battle Creek, US
★★★★★ 5
They already know exactly what you will need and packaged it perfectly!
Style: 24pcs * Accessories Kit
I love my MOVA P10 Ultra and I love that the accessories are reasonably priced. When you use it like I do, you will need the accessories over time. Having it all packaged together is very convenient!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 21, 2026
J
Verified Purchase
Jose
Waukegan, US
★★★★★ 5
Works great for dreame L40 ultra
Style: 24pcs * Accessories Kit
Fits perfectly on my dreame l40 ultra and they are really easy to swap really good quality
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 23, 2026
A
Verified Purchase
Amazon Customer
Cuba, US
★★★★★ 5
Practical and affordable
Style: 24pcs * Accessories Kit
Love this bundle.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2026
W
Verified Purchase
Wahe oz
Houston, US
★★★★★ 4
It gets the job done.
Style: 24pcs * Accessories Kit
The materials aren't high-quality, but they get the job done.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 3, 2026
S
Verified Purchase
Spinenurse
Grantham, US
★★★★★ 5
Exactly as described
Style: 24pcs * Accessories Kit
Delivered in a timely fashion and is just as described. Happy with my purchase
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026

recommand products