SKU: 82283611912

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)

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Description

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)Product Specification Host Rabbit Antigen ALK Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246 Location Cell membrane Accession Q9UM73 Clone Number SDT 3284 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, IMR 32 Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of

Product Specification


Host Rabbit
Antigen ALK
Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246
Location Cell membrane
Accession Q9UM73
Clone Number SDT-3284
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample SH-SY5Y, IMR-32
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu

Background

Anaplastic lymphoma kinase (ALK), also designated CD246, is a single-pass transmembrane receptor tyrosine kinase of the insulin-receptor superfamily that is normally expressed at highest levels in the developing and adult nervous system, where it regulates neuronal differentiation, axon guidance and cognition; the 1620-aa glycoprotein presents an N-terminal extracellular region containing two MAM domains and an LDL-A module for ligand binding, a single hydrophobic transmembrane segment and a C-terminal cytoplasmic kinase domain that, upon ligand-induced dimerization, undergoes trans-autophosphorylation and triggers RAS–MAPK, PI3K–AKT and JAK–STAT signaling cascades controlling cell proliferation and survival. Chromosomal translocations (most famously t(2;5)(p23;q35) producing NPM1–ALK), inversions (EML4–ALK in non-small-cell lung cancer) or activating point mutations cause constitutive kinase activity, driving malignant transformation in anaplastic large-cell lymphoma, subsets of NSCLC, neuroblastoma and inflammatory myofibroblastoma, making the oncoprotein a validated therapeutic target for small-molecule inhibitors such as crizotinib, alectinib and lorlatinib.

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SKU: 82283611912

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4.5 ★★★★★
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Retired Reader
Bozeman, US
★★★★★ 4
Skimming the Surface
Format: Hardcover
The essence of this book is to succinctly explain the role of CIA's National Clandestine Service (Directorate of Operations) in formulating and more importantly executing a coherent counter-terrorism strategy. Gary Berntsen is a retired CIA intelligence officer (clandestine service) with an impressive record of field assignments to his credit. He also clearly knows the ways of Washington D.C. in that this book is designed for those suffering from attention deficit disorder. While he raises several interesting point in the book, he also reveals an astonishing narrowness of view and tendency to reduce everything to its simplest terms. In his introductory `background' chapter Berntsen makes the dubious claim that the collection of intelligence from human sources (HUMINT) is the "primary mission of CIA." Apparently he is unaware that CIA was originally founded to produce all source finished intelligence and that the National Intelligence Council (NIC), until recently under CIA, was the final word in the U.S. Intelligence System. Nothing reveals the sorry state of CIA's Directorate of Intelligence better than this claim. In the same manner Berntsen is apparently oblivious to the availability and uses of intelligence collected by technical means. To his credit he does recognize that the best intelligence is more often available from open (non-classified) sources than from secret sources. Yet he neither expands nor follows up this observation. Berntsen more or less follows this pattern through out this book. For example he provides a brief discussion of the traditional Islamic Banking System called Hawalla, but is apparently unaware that the system is based on a recognized credit not cash and that money does not move across international borders. The system is widely trusted and is widely used by Muslim expatriates in the West and Saudi Arabia to send money home. For this reason Hawalla credit transfers providing money to terrorists are easily lost in a world wide mass of transactions. Yet it is possible to track Hawalla transactions and it has been done without "intensive manpower" allocations. Berntsen deserves a good deal of respect and credit for his obvious service to the U. S. and his dedication to the cause of clandestine intelligence operations and its hand maiden covert operations. Yet this book is a terminally superficial and ill-considered work by someone who not only should know better, but could have produced a first rate `practical guide' to a counter-terrorism strategy.
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Reviewed in the United States on October 30, 2008
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matt crossland
Bozeman, US
★★★★★ 5
Excellent Overview on Counterterrorism
Format: Hardcover
What really sets this book apart from the rest of books on the subject is that it illustrates positive solutions to the problems. It is also a very entertaining and fun read. I would highly recommend this book to anyone concerned over current events and terrorism in our time.
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Reviewed in the United States on April 17, 2014
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Brian
West Palm Beach, US
★★★★★ 4
Good book worth adding to your CIA collection.
Format: Kindle
I enjoyed reading this quite a bit. It's a very fast read that provides an introduction to the layers of the CIA.
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Reviewed in the United States on August 2, 2016
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Reviewer Two
Port Orchard, US
★★★★★ 5
Five Stars
Format: Hardcover
Excellent CIA methofology review
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Reviewed in the United States on May 16, 2017
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Cal Shopper
Charlottesville, US
★★★★★ 5
Five Stars
Format: Hardcover
Excellent
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Reviewed in the United States on March 29, 2016

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