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Description
Biotin Mouse Anti-Rat CD11b/c Antibody (S-R630)Product Specification Host Mouse Antigen CD11b c Synonyms Integrin beta 2 alpha subunit; Itgam; Integrin subunit alpha X; Itgax Location Membrane Accession Q9JI30 Clone Number S R630 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein A Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | CD11b/c |
| Synonyms | Integrin beta 2 alpha subunit; Itgam; Integrin subunit alpha X; Itgax |
| Location | Membrane |
| Accession | Q9JI30 |
| Clone Number | S-R630 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Rt |
Background
CD11b and CD11c are two distinct integrin proteins that play crucial roles in the immune system. CD11b, also known as integrin alpha-M, is primarily expressed on myeloid cells such as macrophages and dendritic cells. It is involved in cell adhesion, migration, and immune cell activation. For example, CD11b ligation promotes pro-inflammatory macrophage signaling and regulates macrophage polarization. CD11c, on the other hand, is mainly found on dendritic cells and is associated with antigen presentation and T cell activation. CD11c+ CD11b+ dendritic cells have been shown to play an important role in the induction of T regulatory cells and the suppression of autoimmune diseases.
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