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Description
SPTB Recombinant Rabbit mAb (S-755-63)Product Specification Host Rabbit Antigen SPTB Synonyms Spectrin beta chain, erythrocytic; Beta I spectrin; SPTB1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession P11277 Clone Number S 755 63 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample SH SY5Y, mouse spleen, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | SPTB |
| Synonyms | Spectrin beta chain, erythrocytic; Beta-I spectrin; SPTB1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P11277 |
| Clone Number | S-755-63 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SH-SY5Y, mouse spleen, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
SPTB (Spectrin Beta Chain, Erythrocytic) is one of the key proteins in the erythrocyte skeleton and belongs to the spectrin family. It is mainly composed of multiple spectrin repeating units, which form a flexible α-helical structure, giving SPTB a high degree of elasticity and mechanical stability. SPTB binds to α-spectrin (SPTA1) to form a heterodimer, which is further assembled into a tetramer, forming the main reticular structure of the erythrocyte skeleton, maintaining the morphology and mechanical strength of erythrocytes, enabling them to withstand shear forces in blood circulation. In addition, SPTB also stabilizes the cell membrane and regulates the mechanical properties of the cell membrane by interacting with other skeleton proteins such as ankyrin, actin, and protein 4.1. SPTB gene mutations can lead to hemolytic anemia diseases such as hereditary spherocytosis because they affect the integrity and function of the erythrocyte skeleton. SPTB is also expressed in non-erythrocytes and participates in processes such as cell morphology maintenance, cell migration, and signal transduction.
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