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Description
R-Spondin2/RSPO2 Protein, MouseProduct Specification Species Mouse Synonyms R spondin 2,Cysteine rich and single thrombospondin domain containing protein 2 (Cristin 2,mCristin 2),Roof plate specific spondin 2 Accession Q8BFU0 Amino Acid Sequence Ala32 Gly205, with N terminal hIgG1 Fc Tag Expression System HEK293 Molecular Weight 46 55 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized powder Storage Buffer
Product Specification
| Species | Mouse |
| Synonyms | R-spondin-2,Cysteine-rich and single thrombospondin domain-containing protein 2 (Cristin-2,mCristin-2),Roof plate-specific spondin-2 |
| Accession | Q8BFU0 |
| Amino Acid Sequence | Ala32-Gly205, with N-terminal hIgG1 Fc Tag |
| Expression System | HEK293 |
| Molecular Weight | 46-55 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Development. 2008 Mar;135(6):1049-58. |
Background
R-Spondin2 (RSPO2) is a member of the R-Spondin family and is a secreted protein that plays a crucial role in regulating Wnt/β-catenin signaling. In mice, R-Spondin2 is essential for various developmental processes. For example, it is required for the maintenance of the apical ectodermal ridge in the hindlimb, which is critical for proper limb development. Additionally, R-Spondin2 is involved in the development of the larynx, trachea, lung, and other organs. It also plays a role in bone formation and mineralization by enhancing Wnt/β-catenin signaling.
R-Spondin2's ability to enhance Wnt signaling makes it a potential candidate for promoting tissue regeneration and repair. It can be used to stimulate osteoblast differentiation and bone formation, which is beneficial for treating bone-related disorders. Also, R-Spondin2 is involved in the regulation of stem cell proliferation and differentiation. Its role in Wnt signaling can be exploited to study cancer stem cells and develop targeted therapies for cancers that involve dysregulated Wnt pathways
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