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Description
Human alpha2-antiplasmin , His tagProduct Specification Species Human Synonyms Alpha 2 AP, Alpha 2 plasmin inhibitor (Alpha 2 PI), Serpin F2, AAP, PLI Accession P08697 Amino Acid Sequence Protein sequence(P08697, Asn40 Lys491, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Alpha-2-AP, Alpha-2-plasmin inhibitor (Alpha-2-PI), Serpin F2, AAP, PLI |
| Accession | P08697 |
| Amino Acid Sequence | Protein sequence(P08697, Asn40-Lys491, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:52.1kDa Actual:60-80kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported. In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease.
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