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Description
CD45 Recombinant Rabbit mAb (S-3361)Product Specification Host Rabbit Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; PTPRC Location Cell membrane, Synapse Accession P08575 Clone Number S 3361 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms Positive Sample J774A. 1, RAW264. 7, moues spleen, mouse thymus Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD45 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; PTPRC |
| Location | Cell membrane, Synapse |
| Accession | P08575 |
| Clone Number | S-3361 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms |
| Positive Sample | J774A.1, RAW264.7, moues spleen, mouse thymus |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:1000 | Ms |
Background
CD45, also known as protein tyrosine phosphatase receptor type C (PTPRC), is a crucial transmembrane glycoprotein expressed on the surface of all nucleated hematopoietic cells except erythrocytes and plasma cells. It is a receptor-like protein tyrosine phosphatase that plays a vital role in regulating immune cell activation and differentiation. CD45 consists of an extracellular domain, a transmembrane segment, and intracellular phosphatase domains. Its primary function is to dephosphorylate specific tyrosine residues on target proteins, thereby modulating signaling pathways essential for immune responses. CD45 has multiple isoforms generated by alternative splicing, which are differentially expressed across immune cell subsets and influence their activation thresholds. For example, naïve T cells predominantly express CD45RA, while memory T cells express CD45RO, which enhances T-cell receptor signaling. In pathology, CD45 is used as a marker to identify hematopoietic cells and distinguish lymphomas from other types of cancer.
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