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Description
LRRK2 Recombinant Rabbit mAb (S-2484-164)Product Specification Host Rabbit Antigen LRRK2 Synonyms Leucine rich repeat serine threonine protein kinase 2; Dardarin; PARK8 Immunogen Synthetic Peptide Location Lysosome, Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion outer membrane Accession Q5S007 Clone Number S 2484 164 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample A549, SH SY5Y, U 87MG, A172, MEF, NIH 3T3, mouse brain,
Product Specification
| Host | Rabbit |
| Antigen | LRRK2 |
| Synonyms | Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; PARK8 |
| Immunogen | Synthetic Peptide |
| Location | Lysosome, Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion outer membrane |
| Accession | Q5S007 |
| Clone Number | S-2484-164 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A549, SH-SY5Y, U-87MG, A172, MEF, NIH/3T3, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
LRRK2 (leucine-rich repeat kinase 2) is a large, multidomain protein belonging to the ROCO family, featuring a Ras-of-complex (ROC) GTPase domain followed by a C-terminal-of-ROC (COR) domain and a serine/threonine kinase domain, along with armadillo, ankyrin, leucine-rich repeat and WD40 repeat regions that collectively mediate protein–protein interactions, membrane association and autoregulation, and whose pathogenic mutations—most notably G2019S in the kinase domain—are the commonest known genetic cause of both familial and sporadic Parkinson’s disease by promoting hyper-kinase activity, mitochondrial fragmentation, autophagic-lysosomal dysfunction and neuronal toxicity.
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