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Description
Invivo Anti-Mouse GITR Recombinant mAbProduct Specification Host Rat Antigen GITR Synonyms Tumor necrosis factor receptor superfamily member 18; Glucocorticoid induced TNFR related protein; CD357; Gitr; Tnfrsf18 Location Cell membrane Accession O35714 Clone Number S 3837 Antibody Type Rat mAb Application FCM, in vivo GITR stimulation Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | GITR |
| Synonyms | Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; CD357; Gitr; Tnfrsf18 |
| Location | Cell membrane |
| Accession | O35714 |
| Clone Number | S-3837 |
| Antibody Type | Rat mAb |
| Application | FCM, in vivo GITR stimulation |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
GITR (glucocorticoid-induced TNF receptor, TNFRSF18/CD357) is a cell-surface receptor of the TNF-receptor superfamily that is constitutively expressed at high levels on regulatory T cells (Tregs) and is rapidly up-regulated on activated CD4⁺/CD8⁺ T cells and NK cells; engagement of GITR by its ligand GITRL (TNFSF18) on antigen-presenting cells delivers a costimulatory signal that activates the NF-κB pathway, enhances IL-2 and IFN-γ production, up-regulates the anti-apoptotic protein Bcl-xL, and thereby amplifies effector T-cell proliferation, cytokine secretion and cytotoxicity while transiently destabilizing FoxP3 and the suppressive function of Tregs, making GITR an attractive target for cancer immunotherapy.
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