Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 4 - Sep 9
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
VDAC1 + VDAC2 + VDAC3 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen VDAC1 + VDAC2 + VDAC3 Synonyms Voltage dependent anion selective channel protein; hVDAC1; Non selective voltage gated ion channel VDAC2; VDAC 2; Non selective voltage gated ion channel VDAC3; VDAC 3; hVDAC3; Outer mitochondrial membrane protein porin 3 Immunogen Synthetic Peptide Location Mitochondrion, Cell membrane, Endoplasmic reticulum Accession P21796Q9MZ15Q9Y277 Antibody Type Polyclonal antibody Isotype
Product Specification
| Host | Rabbit |
| Antigen | VDAC1 + VDAC2 + VDAC3 |
| Synonyms | Voltage-dependent anion-selective channel protein; hVDAC1; Non-selective voltage-gated ion channel VDAC2; VDAC-2; Non-selective voltage-gated ion channel VDAC3; VDAC-3; hVDAC3; Outer mitochondrial membrane protein porin 3 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion, Cell membrane, Endoplasmic reticulum |
| Accession | P21796、Q9MZ15、Q9Y277 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, A431, Jurkat, HEK-293, HepG2, NIH/3T3, mouse heart, PC-12, rat heart |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
Background
VDAC1, VDAC2, and VDAC3 are three closely related ~30 kDa β-barrel porins embedded in the mitochondrial outer membrane where they form voltage-dependent anion channels that collectively serve as the primary gatekeepers for metabolite flux—allowing ATP/ADP, NADH, ion, and other small-molecule exchange between cytosol and mitochondria—while also acting as hubs for Ca²⁺ signaling, apoptotic protein binding, and interaction with hexokinase, creatine kinase, Bcl-2 family proteins, and cytoskeletal elements; despite high sequence similarity, isoforms show tissue-specific expression (VDAC1 ubiquitous, VDAC2 enriched in heart/testis and uniquely anti-apoptotic via Bax inhibition, VDAC3 prominent in testis and cilia with redox-sensitive cysteines linked to sperm motility and ROS regulation), distinct electrophysiological gating properties, and differential roles in oxidative stress, mitochondrial dynamics, and apoptosis, making the trio essential for bioenergetics, cell survival decisions, and increasingly recognized as therapeutic targets in cancer, neurodegeneration, and metabolic disorders.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy