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Description
NFIB / NF1B2 Recombinant Rabbit mAb (S-3046-78)Product Specification Host Rabbit Antigen NFIB NF1B2 Synonyms Nuclear factor 1 B type; NF1 B; Nuclear factor 1 B; CCAAT box binding transcription factor (CTF); Nuclear factor I B (NF I B; NFI B); TGGCA binding protein Immunogen Synthetic Peptide Location Nucleus Accession O00712 Clone Number S 3046 78 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample RPMI 8226, MCF7, HeLa, NIH 3T3 Predicted Reactivity Bv,
Product Specification
| Host | Rabbit |
| Antigen | NFIB / NF1B2 |
| Synonyms | Nuclear factor 1 B-type; NF1-B; Nuclear factor 1/B; CCAAT-box-binding transcription factor (CTF); Nuclear factor I/B (NF-I/B; NFI-B); TGGCA-binding protein |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | O00712 |
| Clone Number | S-3046-78 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | RPMI-8226, MCF7, HeLa, NIH/3T3 |
| Predicted Reactivity | Bv, Hm |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
The NFIB protein, also known as Nuclear Factor I B or NF1B2, is a transcription factor belonging to the NFI (Nuclear Factor I) family of site-specific DNA-binding proteins that play crucial roles in regulating gene expression during development and cellular differentiation. Encoded by the NFIB gene located on human chromosome 9p23-p22, this protein contains a highly conserved N-terminal DNA-binding domain that recognizes the palindromic consensus sequence 5'-TTGGC(N)5GCCAA-3', thereby controlling the transcription of target genes involved in various biological processes including brain development, lung maturation, and skeletal patterning. NFIB functions as both a transcriptional activator and repressor depending on cellular context and promoter architecture, and it forms homodimers or heterodimers with other NFI family members (NFIA, NFIC, and NFID) to exert its regulatory effects. During embryonic development, NFIB is essential for proper formation of the corpus callosum, cerebellar vermis, and facial structures, while in the postnatal period it regulates terminal differentiation of various cell types including chondrocytes, osteoblasts, and respiratory epithelial cells. Aberrant NFIB expression or function has been implicated in multiple pathological conditions, including certain forms of intellectual disability, craniofacial abnormalities, and various cancers where it can act as either an oncogene or tumor suppressor depending on the tissue type. The protein's activity is modulated through post-translational modifications and interactions with various co-activators and co-repressors, making it a critical node in the gene regulatory networks that govern mammalian development and homeostasis.
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