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Description
F4/80 Recombinant Rat mAb (S-942-1)Product Specification Host Rat Antigen F4 80 Synonyms Adhesion G protein coupled receptor E1; Cell surface glycoprotein F4 80; EGF like module receptor 1; EGF like module containing mucin like hormone receptor like 1; EMR1 hormone receptor; Emr1; Gpf480; Adgre1 Immunogen Recombinant Protein Location Cell membrane Accession Q61549 Clone Number S 942 1 Antibody Type Rat mAb Isotype IgG1, Application WB, IHC P, FCM Reactivity Ms Positive Sample RAW264.
Product Specification
| Host | Rat |
| Antigen | F4/80 |
| Synonyms | Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; Emr1; Gpf480; Adgre1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q61549 |
| Clone Number | S-942-1 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,λ |
| Application | WB, IHC-P, FCM |
| Reactivity | Ms |
| Positive Sample | RAW264.7, mouse spleen, BALB/c mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:1000 | Ms |
| FCM | 1:2000 | Ms |
Background
F4/80, also known as ADGRE1 or EMR1, is a cell surface glycoprotein and a member of the EGF-TM7 protein family. It is widely used as a marker for mature mouse macrophages and is highly expressed in various macrophage populations, such as Kupffer cells in the liver, Langerhans cells in the skin, and microglial cells in the brain. However, its expression in human cells is different, being mainly found in eosinophils and some macrophages. F4/80 is an orphan receptor involved in cell adhesion and immune cell interactions, and it may also play a role in the development of regulatory T cells. The protein has a large extracellular domain containing multiple EGF-like calcium-binding domains, linked to a seven-transmembrane domain characteristic of G protein-coupled receptors.
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