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Description
Phospho-Stat2 (Tyr690) Recombinant Rabbit mAb (S-2257-4)Product Specification Host Rabbit Antigen Phospho Stat2 (Tyr690) Synonyms Signal transducer and activator of transcription 2; p113; STAT2 Immunogen Synthetic Peptide Location Nucleus Accession P52630 Clone Number S 2257 4 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Stat2 (Tyr690) |
| Synonyms | Signal transducer and activator of transcription 2; p113; STAT2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P52630 |
| Clone Number | S-2257-4 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
Background
Phospho-Stat2 (Tyr690) is a phosphorylated form of the Stat2 protein, specifically at the tyrosine residue 690. Stat2 is a key component of the JAK-STAT signaling pathway, which is crucial for mediating cellular responses to cytokines such as interferons. When phosphorylated at Tyr690, Stat2 becomes activated and forms complexes with other proteins like Stat1 and IRF9, leading to the formation of the ISGF3 transcription factor complex. This complex then translocates to the nucleus and binds to specific DNA sequences, promoting the expression of interferon-stimulated genes (ISGs) that are essential for antiviral defense, immune regulation, and other cellular processes. The phosphorylation of Stat2 at Tyr690 is a critical step in ensuring the proper transmission of cytokine signals and the subsequent activation of downstream immune responses.
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