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Description
SATB1 Recombinant Rabbit mAb(SDT-073-11)Product Specification Host Rabbit Antigen SATB1 Synonyms Special AT rich sequence binding protein 1 Immunogen Synthetic Peptide Location Nucleus Accession Q01826 Clone Number SDT 073 11 Antibody Type Rabbit mAb Application WB, IHC P, ICC, FC, IP Reactivity Hu Purification Protein A Research Area Neuroscience Concentration 0. 5mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | SATB1 |
| Synonyms | Special AT-rich sequence-binding protein 1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q01826 |
| Clone Number | SDT-073-11 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, FC, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Research Area | Neuroscience |
| Concentration | 0.5mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | |
| ICC | 1:500 | |
| IP | 1:25 | |
| WB | 1:1000 | |
| FC | 1:500 |
Background
SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1 has also been shown to induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.
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