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Description
Mouse Anti-Rat TCR α/β Antibody (S-3806)Product Specification Host Mouse Antigen TCR Location Cell membrane Accession A0A8I6ABG9 Clone Number S 3806 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution
Product Specification
| Host | Mouse |
| Antigen | TCR α/β |
| Location | Cell membrane |
| Accession | A0A8I6ABG9 |
| Clone Number | S-3806 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Rt |
Background
TCR α/β protein, the defining heterodimer of the αβ T-cell lineage, is a disulfide-linked transmembrane receptor whose extracellular amino-terminal variable (Vα/Vβ) and constant (Cα/Cβ) Ig-like domains collectively form an antigen-binding groove that recognizes a composite ligand consisting of a peptide non-covalently nestled within the groove of an MHC molecule; this interaction is stabilized by two paired immunoglobulin superfamily domains and anchored to the T-cell membrane via stalk, transmembrane and short cytoplasmic regions that associate with CD3 γε, δε and ζζ signaling subunits, so that ligand-induced conformational change in the αβ heterodimer triggers phosphorylation of ITAMs and initiates the calcium- and kinase-dependent cascade leading to T-cell activation, proliferation and differentiation, thereby making the TCR α/β protein the central sensor that converts extracellular peptide-MHC information into intracellular immune decisions.
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