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Description
Mouse Anti-Human CD147 Antibody (S-2803)Product Specification Host Mouse Antigen CD147 Synonyms Basigin; 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer (EMMPRIN); Hepatoma associated antigen (HAb18G); Leukocyte activation antigen M6; BSG Location Endosome, Cell membrane, Endoplasmic reticulum Accession P35613 Clone Number S 2803 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood Purification
Product Specification
| Host | Mouse |
| Antigen | CD147 |
| Synonyms | Basigin; 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer (EMMPRIN); Hepatoma-associated antigen (HAb18G); Leukocyte activation antigen M6; BSG |
| Location | Endosome, Cell membrane, Endoplasmic reticulum |
| Accession | P35613 |
| Clone Number | S-2803 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD147, also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or basigin, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is widely expressed in various tissues and cells and plays a crucial role in multiple physiological and pathological processes. CD147 is best known for its ability to induce the expression of matrix metalloproteinases (MMPs), which are involved in extracellular matrix remodeling, tumor invasion, and metastasis. It also regulates glycolysis and is associated with the Warburg effect in cancer cells, promoting tumor growth and resistance to therapy. Additionally, CD147 is involved in inflammation, immune responses, and the pathogenesis of diseases such as asthma, rheumatoid arthritis, and myocardial infarction. In neurological contexts, it contributes to processes ranging from normal retinal function to neuroinflammation in Alzheimer's disease. Its diverse functions and wide expression make it a promising target for therapeutic interventions in various diseases.
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