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Description
GDF-15 Protein, HumanProduct Specification Species Human Synonyms GDF15, GDF 15, MIC 1, MIC1, NAG 1, PDF, PLAB, PTGFB, NRG 1 Accession Q99988 Amino Acid Sequence Ala197 Ile308, with N terminal Human IgG Fc Expression System HEK293 Molecular Weight 38 42kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size
Product Specification
| Species | Human |
| Synonyms | GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, NRG-1 |
| Accession | Q99988 |
| Amino Acid Sequence | Ala197-Ile308, with N-terminal Human IgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 38-42kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Front Immunol . 2020 May 19;11:951. eCollection 2020. |
Background
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is highly expressed in placenta and is expressed at lower levels in kidney, pancreas, prostate and colon. Similarly to other TGF-beta family proteins, GDF-15 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. GDF-15 has been studied to have a wide range of biological functions in physiology and pathology, especially in aging, cancer, and metabolic processes.
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