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Description
PBR/TSPO Recombinant Rabbit mAb (S-607-19)Product Specification Host Rabbit Antigen PBR TSPO Synonyms Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral type benzodiazepine receptor (PBR), BZRP, MBR Immunogen Synthetic Peptide Accession P30536 Clone Number S 607 19 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP Reactivity Hu, Ms Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | PBR/TSPO |
| Synonyms | Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor (PBR), BZRP, MBR |
| Immunogen | Synthetic Peptide |
| Accession | P30536 |
| Clone Number | S-607-19 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, IP |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:25 | |
| IHC | 1:1000 | |
| ICC | 1:250 |
Background
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed. TSPO as a biomarker is a newly discovered non-invasive procedure, and has also been linked as a biomarker for other cardiovascular related diseases including: myocardial infarction (due to ischemic reperfusion), cardiac hypertrophy, atherosclerosis, arrhythmias, and large vessel vasculitis.
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