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Description
LONP1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen LONP1 Synonyms Lon protease homolog, mitochondrial; LONHs; Lon protease like protein (LONP); Mitochondrial ATP dependent protease Lon; Serine protease 15; PRSS15 Immunogen Synthetic Peptide Location Mitochondrion Accession P36776 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HEK 293, HeLa, SH SY5Y, Jurkat, NIH 3T3, C6 Predicted Reactivity Bv
Product Specification
| Host | Rabbit |
| Antigen | LONP1 |
| Synonyms | Lon protease homolog, mitochondrial; LONHs; Lon protease-like protein (LONP); Mitochondrial ATP-dependent protease Lon; Serine protease 15; PRSS15 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P36776 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, HeLa, SH-SY5Y, Jurkat, NIH/3T3, C6 |
| Predicted Reactivity | Bv |
| Purification | Immunogen Affinity |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
LONP1 protein, also known as Lon protease homolog 1, is a nuclear-encoded mitochondrial AAA+ serine protease that plays a crucial role in maintaining mitochondrial homeostasis. It is highly conserved across species and is composed of three functional domains: an N-terminal domain for substrate recognition, an AAA+ domain for ATP binding and hydrolysis, and a protease domain for protein degradation. LONP1 forms a hexameric complex in the mitochondrial matrix and is responsible for degrading misfolded, oxidized, and damaged proteins to prevent their accumulation and maintain mitochondrial proteostasis. Additionally, LONP1 has chaperone-like functions in protein folding and assembly, and it regulates mitochondrial DNA (mtDNA) replication and transcription by interacting with mitochondrial transcription factor A (TFAM). Its dysfunction is associated with various diseases, including mitochondrial disorders and cancer, making it a potential target for therapeutic interventions.
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