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Description
CD209 Recombinant Rabbit mAb (S-1776-31)Product Specification Host Rabbit Antigen CD209 Synonyms CD209 antigen; C type lectin domain family 4 member L; Dendritic cell specific ICAM 3 grabbing non integrin 1 (DC SIGN; DC SIGN1); CLEC4L; Immunogen Synthetic Peptide Location Cell membrane Accession Q9NNX6 Clone Number S 1776 31 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD209 |
| Synonyms | CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN; DC-SIGN1); CLEC4L; |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q9NNX6 |
| Clone Number | S-1776-31 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
CD209, also known as DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-integrin), is a C-type lectin receptor primarily expressed on the surface of dendritic cells, macrophages, and certain endothelial cells. It plays a crucial role in the innate immune system by recognizing and binding to a wide range of pathogens, including viruses, bacteria, and fungi. CD209 is involved in mediating antigen endocytosis and degradation, facilitating the interaction between dendritic cells and T cells, and influencing immune responses. Additionally, it has been implicated in the binding of HIV-1 gp120, contributing to viral entry and infection. Research also suggests that CD209 may regulate macrophage polarization and neutrophil development, highlighting its importance in both innate and adaptive immunity.
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