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Description
Phospho-AMPKα (Thr172) Recombinant Rabbit mAb (S-2216-10)Product Specification Host Rabbit Antigen Phospho AMPK (Thr172) Synonyms 5' AMP activated protein kinase catalytic subunit alpha; AMPK subunit alpha; Acetyl CoA carboxylase kinase (ACACA kinase); Hydroxymethylglutaryl CoA reductase kinase (HMGCR kinase); Tau protein kinase PRKAA1; PRKAA1; AMPK1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13131P54646 Clone Number S 2216 10 Antibody Type Recombinant mAb Isotype IgG Application WB
Product Specification
| Host | Rabbit |
| Antigen | Phospho-AMPKα (Thr172) |
| Synonyms | 5'-AMP-activated protein kinase catalytic subunit alpha; AMPK subunit alpha; Acetyl-CoA carboxylase kinase (ACACA kinase); Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase); Tau-protein kinase PRKAA1; PRKAA1; AMPK1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13131、P54646 |
| Clone Number | S-2216-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:500-1:1000 | Hu, Ms, Rt, Mk |
Background
Phospho-AMPKα (Thr172) protein refers to the catalytic α-subunit of AMP-activated protein kinase that has been phosphorylated on threonine 172, a post-translational modification catalyzed primarily by the upstream kinase LKB1 (or CaMKK2 in response to calcium signals) that is essential for switching AMPK from an inactive to an active conformation; once phosphorylated, this evolutionarily conserved serine/threonine kinase acts as a master cellular energy sensor, triggering catabolic pathways such as fatty-acid oxidation and autophagy while simultaneously inhibiting energy-consuming anabolic processes like gluconeogenesis, lipogenesis and protein synthesis, thereby restoring ATP levels during metabolic stress, and its phosphorylation status is widely used as a biomarker for metabolic activity, exercise physiology, mitochondrial health and the efficacy of drugs ranging from metformin to direct AMPK activators in diabetes, cancer and cardiovascular research.
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