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Description
Phospho-p38 MAPK (Thr180/Tyr182) Recombinant Rabbit mAb (S-3861)Product Specification Host Rabbit Antigen Phospho p38 MAPK (Thr180 Tyr182) Synonyms Mitogen activated protein kinase 14, MAP kinase 14, MAPK14, CSAID binding protein, CSBP, MAP kinase MXI2, MAX interacting protein 2, MAP kinase p38 alpha, SAPK2a Location Cytoplasm, Nucleus Accession Q16539 Clone Number S 3861 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample anisomycin treated Jurkat, anisomycin
Product Specification
| Host | Rabbit |
| Antigen | Phospho-p38 MAPK (Thr180/Tyr182) |
| Synonyms | Mitogen-activated protein kinase 14, MAP kinase 14, MAPK14, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, MAP kinase p38 alpha, SAPK2a |
| Location | Cytoplasm, Nucleus |
| Accession | Q16539 |
| Clone Number | S-3861 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | anisomycin treated Jurkat, anisomycin treated NIH/3T3, anisomycin treated C6, anisomycin treated COS-7 |
| Predicted Reactivity | Dm, Pg, Sc |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| ICC | 1:500 | Hu |
Background
Phospho-p38 MAPK (Thr180/Tyr182) refers to the active form of the p38 mitogen-activated protein kinase that is dually phosphorylated at threonine 180 (Thr180) and tyrosine 182 (Tyr182) within its activation loop. As a central component of the cellular stress response signaling pathway, p38 MAPK is often termed the "stress-activated protein kinase." When cells are exposed to external stressors such as oxidative stress, osmotic shock, UV radiation, or inflammatory cytokines, upstream kinases (e.g., MKK3/MKK6) specifically recognize and phosphorylate these two residues. This dual phosphorylation induces a conformational change in the p38 protein, leading to its full activation. The activated Phospho-p38 MAPK then translocates from the cytoplasm to the nucleus, where it phosphorylates a series of downstream transcription factors (e.g., ATF-2, CHOP, MEF2) and other kinases, ultimately regulating critical biological processes including inflammatory responses, apoptosis, differentiation, autophagy, and cell cycle arrest. Consequently, detecting the level of Phospho-p38 MAPK (Thr180/Tyr182) serves as the most direct and crucial molecular indicator for assessing the activation status of the p38 MAPK pathway within cells, and it is widely utilized in fields such as immunology, neuroscience, cancer research, and drug development.
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