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Description
Dopamine D (2) Receptor/D2R Recombinant Rabbit mAb (S-2127-37)Product Specification Host Rabbit Antigen Dopamine D (2) Receptor D2R Synonyms D (2) dopamine receptor; Dopamine D2 receptor; DRD2 Immunogen Synthetic Peptide Location Cell membrane Accession P14416 Clone Number S 2127 37 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample Caco 2, SH SY5Y, PANC 1, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Dopamine D (2) Receptor/D2R |
| Synonyms | D (2) dopamine receptor; Dopamine D2 receptor; DRD2 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P14416 |
| Clone Number | S-2127-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, SH-SY5Y, PANC-1, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
The dopamine D2 receptor (D2R) is a G protein-coupled receptor encoded by the DRD2 gene, playing a crucial role in the central nervous system. It is the main target for most antipsychotic drugs and is involved in regulating various functions such as motor control, reward, and memory. D2R is coupled to the Gi subtype of G protein, inhibiting adenylyl cyclase activity. In addition to its canonical G protein signaling, D2R also signals through β-arrestin pathways, which can be selectively targeted to potentially improve therapeutic outcomes. Research has shown that D2R is involved in synaptic plasticity and memory formation in mice, and it may protect dopamine neurons from cell death in conditions mimicking Parkinson's disease.
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