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Description
OSMR/IL-31RB His Tag Protein, HumanProduct Specification Species Human Antigen OSMR IL 31RB Synonyms OSMRB,PLCA1, IL 31RB,OSMR beta,IL 31R beta Accession Q99650 Amino Acid Sequence Glu28 Met740, with C terminal 10*His
Product Specification
| Species | Human |
| Antigen | OSMR/IL-31RB |
| Synonyms | OSMRB,PLCA1, IL-31RB,OSMR beta,IL-31R-beta |
| Accession | Q99650 |
| Amino Acid Sequence | Glu28-Met740, with C-terminal 10*His ERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 100-120 kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Qing Guo, Ge‐fei Guan, Jing‐yuan Cao, Cun‐yi Zou, Chen Zhu, Wen Cheng. Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. OR IGINAL RESEARCH ARTICLE. |
Background
Oncostatin M receptor (OSMR), also named as IL‐31R‐β, is a cytokine receptor gene of IL‐6 family and transduces oncostatin M (OSM) and IL‐31 signaling. A recent study shows that OSMR expression is elevated in GBM, especially mesenchymal subtype. OSM/OSMR signaling has been shown to play an important role in driving the glioma cells towards mesenchymal type, and correlated with poor survival. Moreover, OSMR is a direct transcriptional target gene of STAT3 and forms a physical complex with epidermal growth factor receptor vIII (EGFRvIII), a truncated EGFR in which exons 2−7 are deleted. OSMR also promotes the proliferation of human brain tumor stem cells (BTSCs) and the depletion of OSMR impaired EGFRvIII‐STAT3 signaling. OSMR may be a key factor and related to JAK/STAT signaling in mediating the effect of endogenous bornavirus‐like nucleoprotein elements on the proliferation and apoptosis of oligodendroglia cells.
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