SKU: 99426201765

Zoetis INFORCE 3® Respiratory Vaccine

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Description

Zoetis INFORCE 3® Respiratory VaccineRespiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3 the market leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young

Respiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3® the market-leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young as 3 days old, at weaning, before moving to group pens, or with cows and heifers at prefreshening.

Indications
Helps protect against respiratory disease caused by BRSV, IBR and PI3.
Available As

Vials

For use with

Beef

Dairy

How it Works

As an intranasal respiratory vaccine, INFORCE 3® causes a local immune response with viral antibodies produced in the nasal passage where BRSV, IBR and PI3 are most likely to enter the animal’s system.

INFORCE 3® is the first commercially-available intranasal respiratory vaccine to help protect against respiratory disease caused by BRSV, while also protecting against IBR and PI3, to help get cattle off to a healthier, more productive start.

INFORCE 3 has a six-month duration of immunity claim for IBR protection, and a single-nostril administration claim. Additional research also demonstrated no maternal antibody interference for IBR and BRSV.2,3

Safe for all ages, types and classes of cattle

INFORCE 3® is safe for use in all types, ages and classes of cattle. INFORCE 3 was demonstrated safe for use in very young, high-stress calves; weaned and high-stress stocker calves; and pregnant heifers and cows.

The Science Behind Effective Control

  • Intranasal administration works with the animal's immune system for fast, effective response
  • Helps prime the immune system for a memory response to subsequent vaccinations as well as disease challenges
  • Contains proprietary, temperature-sensitive IBR and PI3 strains that replicate most effectively in the upper respiratory tract
  • Stimulates interferon release for protection
  • Helps deliver a healthy start for young dairy calves

Proven Respiratory Disease Protection

  • In two different studies, all calves vaccinated with INFORCE 3 survived severe BRSV challenges in which 100% and 90% of unvaccinated controls either died or had to be humanely euthanized.4,5
  • INFORCE 3 was shown to help prevent respiratory disease caused by IBR and PI3 and reduce level and duration of viral shedding caused by IBR and PI3.6-8
  • A study comparing INFORCE 3 and TSV-2® demonstrated that vaccinating cows and heifers with INFORCE 3  prior to freshening helped support overall positive production:
    • 205 pounds more milk per cow per lactation9
    • Increased income per cow9

Directions

Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, mix well and administer 2 mL intranasally using a cannula. Place the 2-mL dose in a single nostril or place 1-mL in each nostril. 

Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization. Annual revaccination with a single dose is recommended. 

For further advice on revaccination frequency, consult your veterinarian.

PRECAUTIONS:

  1. Store at 2°-8°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

  2. Use entire contents when first opened.

  3. Sterilized syringes should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

  4. Inactivate unused contents before disposal.

  5. Do not vaccinate within 21 days before slaughter.

  6. Contains gentamicin as preservative.

  7. Fetal health risks associated with the vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined during clinical trials conducted for licensure. Appropriate strategies to address the risks associated with modified live vaccine use in pregnant animals should be discussed with a veterinarian.

  8. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

References

  1. Based on number of doses and overall sales of respiratory vaccines. Animalytics Segment Data, Biologicals Therapeutic Category, Ending MAT May 2021.
  2. Mahan SM, Sobecki B, Johnson J, et al. Efficacy of Intranasal Vaccination With a Multivalent Vaccine Containing Temperature-Sensitive Modified-Live Bovine Herpesvirus Type 1 for Protection of Seronegative and Seropositive Calves Against Respiratory Disease. J Am Vet Med Assoc. 2016;248(11):1280-1286.
  3. Ellis JA, Gow SP, Mahan S, Leyh R. Duration of Immunity to Experimental Infection With Bovine Respiratory Syncytial Virus Following Intranasal Vaccination of Young Passively Immune Calves. J Am Vet Med Assoc. 2013;243(11):1602-1608.
  4. Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.
  5. Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.
  6. Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.
  7. Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.
  8. Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.
  9. Data on file, Study Report No. 10PETINF01, Zoetis Inc.
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SKU: 99426201765

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M
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Megan Kennedy
Cuba, US
★★★★★ 3
I wanted to like this more than I did
Format: Kindle
This started off so well! I thought it was going to take Lola on a run for her money but it ended up getting weird. I liked the writing but there was just too much spice which I didn't think was possible for me. There were too many times that the writing felt weird or the situations too outlandish and unrealistic. I had to skim through a lot of the later half. It might just be the dynamic between the characters that didn't work for me so I'll give this author another go.
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Reviewed in the United States on February 7, 2025
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JB
Lake Worth, US
★★★★★ 5
love love love!!
Format: Kindle
Unwanted is the perfect hurt/comfort romance read. I LOVE an OV romance where the beta is the center of the story and Song delivers a heartfelt story of a single mom to 2, burned by her alpha-hole ex starting her life over in the small town of Knotty Pines. Reid and Finn are an alpha/omega pair who’ve been together since they scent matched as teenagers, they’ve always known someone was missing in their lives and they’ll stop at nothing to prove to Cammie that her, Em & Ben are everything they always wanted. I couldn’t put this one down - Song tugs at your heart strings, and gives you vulnerable, real and lovable characters with depth and relatability. The book is so well paced, detailed to perfection without overdoing it or straying, I really honestly loved the flow and details in this story and the banter and humor had me smiling throughout this read. This was the perfect hurt/comfort, who did this to you, fated mates, stop at nothing to get the girl romance that I’ll be recommending for the foreseeable future!!
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Reviewed in the United States on June 26, 2024
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M
Omaha, US
★★★★★ 4
Oh this was adorable and cozy and spicy
Format: Kindle
Oh this was adorable and cozy and spicy and I had so much fun with this book! The relationship between Cammie, Finn and Reid is good. I love how doting both men are of her and her kids, always providing them with a safe space to be themselves. They were patient with Ben and I loved seeing that represented in this book. The plot was done well and it was well paced with quiet, family moments as well as drama to keep us on our toes. I do wish we'd gotten more moments just between Finn and Reid to showcase their strong relationship (they've been together for two decades!) and while we got something, both men were first and foremost focused on Cammie. It makes sense why this was, there was a lot of hurt that needed to be soothed and I'm glad she is treated like the queen she is, but I did yearn for more of the alpha-omega couple.
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Reviewed in the United States on September 29, 2025
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kindleafterdark
New York, US
★★★★★ 5
A Beta’s Dream!
Format: Kindle
I loved this book!! Unwanted follows Cammie, a single mom and Beta, working two jobs, trying her best to raise a son and daughter since her a$$hole ex Alpha kicked them out after meeting his scent match. Being a Beta from the wrong side of the tracks, Cammie is often the victim of rumors and blatant disrespect from several alphas in town; and while in a panic searching for her daughter who somehow managed to wander outside of the home, she finds herself in a panic when she comes across a police officer. Rather than help her, Cammie finds herself feeling threatened and helpless against the alpha’s behavior. That’s when Reid, one of her Alpha neighbors (and super hot firefighter) swoops in to her rescue. Sparks fly, but Cammie thinks nothing of it since she is so used to being disregarded. Little does she know, Reid goes home to his Omega, the adorable and caring Finn, and confesses that he thinks he’s met their match. What follows is a beautiful hurt/comfort romance, with lots of steam, and found family perfection! Reid and Finn worship Cammie and absolutely adore her kids. They’ll do anything to protect them and cherish them, to erase all the hurt and rejection that their bio dad put them through. It’s such a heart warming and emotional story—perfect for when you’re feeling like something low angst with princess treatment for not just Cammie, but her kids as well. I definitely recommend picking this one up!!
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Reviewed in the United States on June 28, 2024
L
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Lisa Maddison
Bozeman, US
★★★★★ 5
Emotional read with children
Format: Kindle
Cammie is a single mother of two children whose ex-boyfriend, who is an alpha that he met his scent matched omega and dumped her via messenger on his phone then the next day put their house up for sale. Cammie moves back to her hometown, but because she has no support, is working two jobs to keep her and the children in a small rented house. One night her four year gets out of the house and she meets a neighbour, but she refuses to make the same mistake again by getting involved with another alpha, but Reid is convinced they are scent matched mates even though Cammie is a beta. Reid and his omega Fin start to court Cammie and her two children that they belong together as a pack and family. Cammie's ten year old son is a tough one to convince, but the scenes between him and Reid and Fin, they were so good. I was tearing up at times, found family was a big theme and I really liked this book. I highly recommend that you try it too.
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Reviewed in the United States on February 16, 2025

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