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Description
S-RMab® PD-1 Recombinant Mouse mAb,PBS Only (SDT-R143)Product Specification Host Mouse Antigen PD 1 Synonyms Programmed cell death protein 1, hPD 1, CD279 Immunogen N A Location Cell membrane Accession Q15116 Clone Number SDT R143 Antibody Type Recombinant mAb Isotype IgG1 Application WB, IHC P, ICC, IP, IF, ICFCM Reactivity Hu Purification Protein G Concentration 2 mg ml Tag N A Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt, 4C as supplied Dilution
Product Specification
| Host | Mouse |
| Antigen | PD-1 |
| Synonyms | Programmed cell death protein 1, hPD-1, CD279 |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | Q15116 |
| Clone Number | SDT-R143 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1 |
| Application | WB, IHC-P, ICC, IP, IF, ICFCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt, 4°C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:200-1:500 | |
| ICFCM | 1:200 | |
| ICC | 1:100 | |
| WB | 1:1000 | |
| IP | 1:200 | |
| IF | 1:200 |
Background
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
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Exchange/Return Notes
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