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Description
NA/LE Mouse anti-human CD3 mAbProduct Specification Host Mouse Antigen CD3 Synonyms T cell surface antigen T3 Leu 4 epsilon chain, CD3e, T3E Immunogen N A Accession P07766 Clone Number OKT3 Antibody Type Mouse mAb Isotype IgG2a,k Isotype Control Invivo mouse IgG2a isotype control Application FC, Functional Assay, in vitro T cell stimulation activation Reactivity Hu Purification Protein A Concentration Lot specific* (generally 0. 5 to 5 mg ml)* Endotoxin 1EU mg Conjugation
Product Specification
| Host | Mouse |
| Antigen | CD3 |
| Synonyms | T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E |
| Immunogen | N/A |
| Accession | P07766 |
| Clone Number | OKT3 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Isotype Control | Invivo mouse IgG2a isotype control |
| Application | FC, Functional Assay, in vitro T cell stimulation/activation |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | Lot specific* (generally 0.5 to 5 mg/ml)* |
| Endotoxin | ＜1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Dilution
| application | dilution | species |
| Functional Assay | 1:500 | |
| FC | 1:500 |
Background
This antibody recognizes the same epitope as clone OKT3.
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex. The CD3–T cell receptor (TCR) complex plays a central role in the T-cell-mediated immunoresponse as it is involved in the recognition of antigens and subsequent signal transduction and activation of immunocompetent T lymphocytes. Because CD3 is required for T cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes and other autoimmune diseases.
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