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Description
FOLR4 His Tag Protein, HumanProduct Specification Species Human Synonyms FOLR4, Folbp3, FR delta, LOC390243 Accession A6ND01 Amino Acid Sequence Gly20 Ser228, with C terminal His Expression System HEK293 Molecular Weight 27 30kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | FOLR4, Folbp3, FR-delta, LOC390243 |
| Accession | A6ND01 |
| Amino Acid Sequence | Gly20-Ser228, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 27-30kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Matsumura et al. (2021) Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Front Cell Dev Biol. 9: 810118. 2、Noda et al. (2020) Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci USA. 117(21): 11493-11502. |
Background
FOLR4, also known as Sperm-egg fusion protein Juno (IZUMO1R) is receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. First, mammalian spermatozoa undergo the acrosome reaction to become fusion-competent. Then, the acrosome-reacted spermatozoa penetrate the zona pellucida and adhere to and finally fuse with the egg plasma membrane. IZUMO1 is the first sperm protein proven to be essential for sperm-egg fusion in mammals. Sperm-oocyte membrane fusion is one of the most important events for fertilization. So far, IZUMO1 and Fertilization Influencing Membrane Protein (FIMP) on the sperm membrane and CD9 and JUNO (IZUMO1R/FOLR4) on the oocyte membrane have been identified as fusion-required proteins. However, the molecular mechanisms for sperm-oocyte fusion are still unclear. Here, we show that testis-enriched genes, sperm-oocyte fusion required 1 (Sof1/Llcfc1/1700034O15Rik), transmembrane protein 95 (Tmem95), and sperm acrosome associated 6 (Spaca6), encode sperm proteins required for sperm-oocyte fusion in mice. These knockout (KO) spermatozoa carry IZUMO1 but cannot fuse with the oocyte plasma membrane, leading to male sterility.
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4.1 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
Must have for any occasion!
Size: 9 Ounce (Pack of 2)
This jerky is hands down the best flavor and tenderness I’ve ever had from a bag of jerky. Honestly do yourself a favor and don’t open the bag unless you’re committed to eating the whole bag in one sitting.
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Reviewed in the United States on May 26, 2026
★★★★★ 5
Tasty treat in single serve packs! My new favorite snack
Set name: Baby Blues BBQ, 2 Ounce Pack of 8
A friend recommended the Righteous Felon Beef Jerky, so I decided to give it a try.
The Baby Blues BBQ is the perfect balance of BBQ with a hit of hot. It's not overwhelming and doesn't make you run for a glass of water, but just enough to add flavor. The texture of the beef is the right balance between tender, jerky and not dried out or tough. Just right.
I am glad that each packet is a single serving because it's easy to enjoy a small bag by one's self.
Packaging is cute.
I wikk be trying a number of the other flavors as soon as I finish these, which will be quite soon at the rate I'm going. Haha
It's a nice treat.
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Reviewed in the United States on May 12, 2026
★★★★★ 5
Definitely will buy again
Set name: Seoul Survivor, 2 Ounce Pack of 8
Excellent. Strong flavor, but not too strong.
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Reviewed in the United States on May 4, 2026
★★★★★ 5
Macro friendly
Set name: Truffle-O-Soldier, 2 Ounce Pack of 8
This jerky is so good to snack on with awesome macros. Would recommend!
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Reviewed in the United States on February 9, 2026
★★★★★ 5
It is some of the best jerky
Set name: Baby Blues BBQ, 2 Ounce Pack of 8
this stuff is sooooo good! I like that it is a size that can keep fresh I keep purchasing it
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Reviewed in the United States on May 23, 2025