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Description
Invivo anti-Human/Mouse CD11B Recombinant mAbProduct Specification Host Rat Antigen CD11b Synonyms Integrin alpha M; CD11 antigen like family member B; CR 3 alpha chain; Cell surface glycoprotein MAC 1 subunit alpha; Leukocyte adhesion receptor MO1; Itgam Location Cell membrane Accession P05555P11215 Clone Number S R574 1 Antibody Type Rat mAb Isotype Rat IgG2b,k Application FCM, in vivo CD11b neutralization Reactivity Hu, Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G
Product Specification
| Host | Rat |
| Antigen | CD11b |
| Synonyms | Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Itgam |
| Location | Cell membrane |
| Accession | P05555、P11215 |
| Clone Number | S-R574-1 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2b,k |
| Application | FCM, in vivo CD11b neutralization |
| Reactivity | Hu, Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:500 | Hu, Ms |
Background
CD11b, also known as integrin alpha M (ITGAM), is a cell surface receptor belonging to the integrin family and primarily expressed on immune cells such as macrophages, monocytes, neutrophils, and NK cells. It forms a heterodimer with CD18 to create the β2 integrin complex, which is crucial for mediating cell adhesion, migration, and immune responses. CD11b plays a significant role in leukocyte recruitment and activation during inflammation and immune responses by interacting with ligands like ICAM-1 and iC3b. Additionally, it is involved in phagocytosis and immune regulation in various diseases, including cancer and autoimmune conditions.
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