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Description
Fc γ RIIB/CD32b His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms Fc gamma RIIB , CD32b; Fc gamma Receptor IIB C, CD32, CD32b,CDw32 Accession Q8SPW3 1 Amino Acid Sequence Ala46 Pro224, with C terminal His Expression System HEK293 Molecular Weight 30 35kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 2 Reconstitution Reconstitute at
Product Specification
| Species | Cynomolgus |
| Synonyms | Fc gamma RIIB , CD32b;Fc gamma Receptor IIB/C, CD32, CD32b,CDw32 |
| Accession | Q8SPW3-1 |
| Amino Acid Sequence | Ala46-Pro224, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 30-35kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.2 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16) can produce multiple subtypes. There are three human Fc γ RII / CD32 genes (A, B and C), two crab eating monkeys (An and B), and one Fc γ RII B in mice. Fc γ RIIB is also called CD32b, FCG2, IGFR2. In the extracellular domain, the homology of cynomolgus monkey CD32b with human, mouse and rat is 90%, 64% and 61%, respectively. CD32 is a low affinity receptor of IgG. Fc γ RIIB was expressed on B cells, dendritic cells, monocytes, macrophages and mast cells, and had the highest affinity to IgG1, followed by IgG3, IgG4 and IgG2. Fc γ RII B can regulate the survival of plasma cells, maintain the stability of the internal environment, inhibit the maturation of dendritic cells and the release of type I interferon, inhibit the antigen presentation of mature dendritic cells, and inhibit cell phagocytosis, antibody-dependent cytotoxicity and the release of inflammatory mediators.
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