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Description
Presepsin Recombinant Rabbit mAb (SDT-2138-29)Product Specification Host Rabbit Antigen Presepsin Synonyms N terminal of soluble CD14 (sCD14), sCD14 ST Immunogen Recombinant Protein Clone Number SDT 2138 29 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against IL 6 Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | Presepsin |
| Synonyms | N-terminal of soluble CD14 (sCD14), sCD14-ST |
| Immunogen | Recombinant Protein |
| Clone Number | SDT-2138-29 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against IL-6 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
The soluble cluster of differentiation 14 subtype, presepsin, is a novel and promising biomarker identified in 2005. Presepsin is a soluble N-terminal fragment of the cluster of differentiation (CD) marker protein CD14. CD14 is a free fragment of glycoprotein expressed on monocyte and macrophage. It is a receptor of lipopolysaccharide–lipopolysaccharide-binding protein (LPS-LBP) complexes, transducing the endotoxin signal from bacterial infection through the Toll-like receptor-4. Its soluble form, soluble CD14 (sSD14), is produced from cell secretion or when membrane-bound, CD14 (mCD14) detaches from cells such as phagocytes. The N-terminal fragments of 13 kDa consist of sCD14 subtype (sCD14-ST; presepsin) are related to mediating the immune response to LPS. PCT level increases in 8–24 h and reaches the peak later than 24 h after infection, while presepsin level typically increases within 2 h and reaches the peak in 3 h. Presepsin was reported to have diagnostic and prognostic abilities in patients with sepsis in some studies performed according to the previous Sepsis-2 definitions. A systematic review and meta-analysis showed that the diagnostic accuracy of presepsin in detecting infection was similar to that of PCT, and both biomarkers were useful for the early diagnosis of sepsis.
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