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Description
Human FIS1 Protein, His tagProduct Specification Species Human Synonyms Mitochondrial fission 1 protein, FIS1 homolog (hFis1), Tetratricopeptide repeat protein 11 (TPR repeat protein 11), TTC11 Accession Q9Y3D6 Amino Acid Sequence Protein sequence (Q9Y3D6, Met1 Gly122, with C His tag) MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDG Expression System HEK293 Molecular Weight Predicted MW: 15. 9 kDa
Product Specification
| Species | Human |
| Synonyms | Mitochondrial fission 1 protein, FIS1 homolog (hFis1), Tetratricopeptide repeat protein 11 (TPR repeat protein 11), TTC11 |
| Accession | Q9Y3D6 |
| Amino Acid Sequence | Protein sequence (Q9Y3D6, Met1-Gly122, with C-His tag) MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDG |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 15.9 kDa Observed MW: 16 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Mitochondrial fission 1 protein (Fis1) is a key regulator in mitochondrial fission, a process critical for maintaining mitochondrial dynamics and cellular homeostasis. Localized to the outer mitochondrial membrane, Fis1 recruits cytosolic dynamin-related proteins (e.g., Drp1) to drive mitochondrial fragmentation. Dysregulation of Fis1-mediated fission is linked to various cellular stress responses, apoptosis, and diseases such as neurodegenerative disorders and cancer. Research focuses on its interaction networks, post-translational modifications, and roles in mitochondrial quality control, shedding light on mechanisms underlying mitochondrial dysfunction and potential therapeutic targets.
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