SKU: 59659877718

FITC Rat Anti-Mouse Ly6C Antibody (S-4036)

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Description

FITC Rat Anti-Mouse Ly6C Antibody (S-4036)Product Specification Host Rat Antigen Ly 6C Synonyms Lymphocyte antigen 6C1; Ly 6C1; Ly6c1 Location Cell membrane Accession P0CW02 Clone Number S 4036 Antibody Type Rat mAb Isotype IgG2a Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 5 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rat
Antigen Ly-6C
Synonyms Lymphocyte antigen 6C1; Ly-6C1; Ly6c1
Location Cell membrane
Accession P0CW02
Clone Number S-4036
Antibody Type Rat mAb
Isotype IgG2a
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse bone marrow
Purification Protein G
Concentration 0.5 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 0.25μg per million cells in 100μl volume Ms

Background

Ly-6C is a glycosylphosphatidylinositol-anchored cell-surface protein belonging to the Ly-6/uPAR/α-neurotoxin superfamily, selectively expressed on murine monocyte and T-cell subsets where it serves as a dynamic lineage and activation marker—its high level on pro-inflammatory “classical” monocytes (CD11b⁺Ly-6C^hi) enables their recruitment via CCR2 to inflamed tissues, whereas Ly-6C^lo monocytes patrol vasculature and replenish resident macrophages, and transient up-regulation on CD8⁺ T cells correlates with effector differentiation; structurally it forms a three-finger α-helical bundle that can laterally associate with lipid rafts and signaling partners such as T-cell receptor or integrin complexes to modulate calcium flux, cytokine release, and adhesion, thereby critically steering innate–adaptive immune crosstalk in infections, autoimmunity, and cardiovascular disease.

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SKU: 59659877718

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4.9 ★★★★★
Based on 17 reviews
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Product Reviews
A
Verified Purchase
Anne L
New York, US
★★★★★ 5
Long lasting dog treat
Flavor Name: Bacon, Size: 1 Count (Pack of 1)
My dog absolutely loved this stuffed shin bone—it kept her occupied way longer than most treats, which is always a win. It’s a great option when you need something that will actually hold their attention. What I Loved:    •   Long-lasting chew compared to typical treats    •   The stuffing inside keeps dogs interested and engaged    •   Helps with boredom and keeps them busy    •   Once finished, the bone can be reused with other fillings One Small Con:    •   It can get a little messy depending on how your dog chews, so it’s best to give it in an easy-to-clean area Who It’s Best For: Perfect for medium to strong chewers or dogs that need something to keep them occupied for a while. Final Verdict: This is a great value and a go-to for keeping dogs entertained. I’d definitely recommend it if you’re looking for a longer-lasting treat that your dog will actually stick with! 🐾
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Reviewed in the United States on April 11, 2026
N
Verified Purchase
nappydrew
Draper, US
★★★★★ 5
🦴 The Ultimate Distraction: A Must-Have for Power Chewers!
Flavor Name: Bacon, Size: 1 Count (Pack of 1)
Finding a chew toy that can withstand my 70-pound "House Hippo" (an expert-level destructor) for more than ten minutes felt impossible, until we discovered these stuffed shin bones. These treats are an absolute game-changer for long-lasting entertainment, durability, and distraction. Exceptional Durability and Value: The bone itself is thick, natural, and surprisingly sturdy. Unlike processed chews that crumble or get demolished instantly, these last for days of chewing. The value is tremendous because they provide two phases of entertainment: first, the intense effort of licking out the filling, and second, the satisfying work of chewing the bone itself afterward. Irresistible Appeal (Peanut Butter/Cheese Filling): The filling is the secret weapon! My dog goes absolutely wild for the flavor. The filling is firmly packed inside, which means he has to spend a significant amount of time actively working to get every last bit. This intense focus buys me hours of peace and quiet, which is invaluable. On top of that, they offer good nutrition! Less Mess, More Fun: I appreciate that these bones are relatively neat. They don't leave greasy residue all over the carpet like some marrow bones, and the durable exterior means minimal splintering (though, as with any bone, supervision is required). They satisfy my dog's natural chewing instinct while promoting dental health by scraping against his teeth as he works the chew. Final Verdict: If you have an aggressive chewer who needs a serious, long-lasting treat that is both entertaining and structurally sound, look no further. These stuffed bones deliver on their promise and are now a staple in our dog treat rotation!
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Reviewed in the United States on October 4, 2025
M
Verified Purchase
Mandi Mills
Natrona Heights, US
★★★★★ 5
Still Going Strong Months Later
Flavor Name: Bacon, Size: 1 Count (Pack of 1)
These stuffed chew bones have been amazing for my dogs. Even months later, they’re still happily chewing on them, and that says a lot since they’re aggressive chewers. The bacon and cheese filling keeps them interested, and the bones themselves are durable enough to handle their chewing without falling apart. After all this time, the chews are still holding up and my dogs love them every time. They keep my dogs busy, help with dental care, and are definitely worth having on hand for large dogs who love to chew. Durable, tasty, and long-lasting—can’t ask for more.
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Reviewed in the United States on February 10, 2026
C
Verified Purchase
Christy
Lowell, US
★★★★★ 5
Long lasting
Flavor Name: Bacon, Size: 1 Count (Pack of 1)
These are the longest lasting bones I have ever purchased. But if you don't want a heavy bone that makes noise when dropped this is not for you. They go sliding across my floor as they are being tossed around and played with. But they love them and they have lasted for months. I am glad they are not as expensive as others. To many things are over priced. Dogs love them.
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Reviewed in the United States on May 14, 2026
A
Verified Purchase
Amazon Customer
Pawtucket, US
★★★★★ 4
Arrived on time and as described
Flavor Name: Bacon, Size: 1 Count (Pack of 1)
It is perfect for my 120 lb dog. He did give up after 6 hours of trying to get the “stuffing” out. The bone held up to his chewing. He loved it!
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Reviewed in the United States on January 14, 2026

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